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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized by a focus on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and participants from different geographic areas. This kind of heterogeneity is necessary for pragmatic trials to be valid and also helps reduce bias in the results. However, too much heterogeneity, can cause problems with the trial design.

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Pragmatic trials seek to replicate real-life situations and attain maximum external validity. They are usually commissioned by policy makers and 프라그마틱 게임 (socialmarkz.com published a blog post) practitioners to guide their decision-making. They can also be used to assess the cause-effect relationship of an intervention with its outcomes. However, they should not be used in lieu for the use of explanation trials.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in policy and 프라그마틱 슬롯 환수율 practice decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study that includes the recruitment, design, and delivery of the intervention, and follow-up.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, which are shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to note, however, that the majority were conducted in primary-care settings.