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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.

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A practical trial that employs a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is required for pragmatic trials to be able to prove their validity, and it also helps reduce the chance of bias in the results. However excessive heterogeneity could result in problems with the design of the trial.

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The goal of pragmatic trials is to mimic real-life situations and achieve maximum validity externally. They are usually commissioned by practitioners and 프라그마틱 슬롯 무료 policy makers to inform their decision making. They also provide a useful way to identify the causality between the intervention and its effects. However, they shouldn't be used in lieu for the use of explanation trials.

The pragmatism idea is controversial, and there are concerns about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which confirm a physiological hypothesis or 프라그마틱 순위 clinical hypothesis, as well as pragmatic trials, that inform policy and practice decision-making. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the traits of a pragmatic study that includes recruitment, design, implementation of the intervention and 프라그마틱 무료게임 its follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. However, it is important to keep in mind that the majority of these studies were conducted in primary care settings.